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Quercetin (found in apples, onions, and tea) exhibits neuroprotective effects in toxin‐induced PD models by reducing oxidative stress, particularly in the cerebellum [15, 39] Clinical interest in flavonoids is growing

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In OA research, recent evidence indicates that pharmacological activation of the Nrf2–GPX4 signaling axis using bioactive natural products or synthetic small molecule agonists can effectively mitigate ferroptosis in vitro cultured chondrocytes and in vivo OA animal models, while significantly suppressing ECM degradation progression (Wu et al., 2025b